Male-Dependent Promotion of Colitis in 129 Rag2−/− Mice Co-Infected with Helicobacter pylori and Helicobacter hepaticus

The prevalence of gastric Helicobacter pylori (Hp) infection is ~50% of the world population. However, how Hp infection influences inflammatory bowel disease in humans is not fully defined. In this study, we examined whether co-infection with Hp influenced Helicobacter hepaticus (Hh)–induced intestinal pathology in Rag2^−/− mice. Rag2^−/− mice of both sexes were infected with Hh, of which a subgroup was followed by infection with Hp two weeks later. Co-infected males, but not females, had significantly higher total colitis index scores in the colon at both 10 and 21 weeks post-Hh infection (WPI) and developed more severe dysplasia at 21 WPI compared with mono-Hh males. There were no significant differences in colonization levels of gastric Hp and colonic Hh between sexes or time-points. In addition, mRNA levels of colonic Il-1β, Ifnγ, Tnfα, Il-17A, Il-17F, Il-18, and Il-23, which play important roles in the development and function of proinflammatory innate lymphoid cell groups 1 and 3, were significantly up-regulated in the dually infected males compared with mono-Hh males at 21 WPI. These data suggest that concomitant Hp infection enhances the inflammatory responses in the colon of-Hh-infected Rag2^−/− males, which results in more severe colitis and dysplasia.     

含氟无皂乳液P(CTFE-IBVE-SUA)的合成及性能研究

通过无皂乳液聚合法制备得到聚(三氟氯乙烯-乙烯基异丁基醚-十一烯酸钠)[P(CTFE-IBVE-SUA)]含氟乳液。考察了单体配比对聚合反应的影响,研究了SUA用量对乳液及聚合物性能的影响,并对聚合物的结构及乳胶粒的形貌进行了测定。结果表明:含氟无皂乳液P(CTFE-IBVE-SUA)的稳定性好、粒径分布均匀;改变单体配比中IBVE和CTFE的比例可以得到不同结构的含氟聚合物乳液;SUA用量对乳液的稳定性、乳胶粒的粒径大小及粒径分布、聚合物膜与水的接触角都有很大的影响;制得的乳液具有明显的核壳结构。     

不同熄焦方式对40kg焦炉焦炭质量的影响

不同熄焦方式对焦炭的冷态强度、热态强度以及生产焦炉的工艺特点均有影响,为了更好地指导40 kg试验焦炉的生产,需对比分析水熄焦、干熄焦方式对焦炭质量的影响。选用4种不同炼焦煤和1种生产配合煤,利用40 kg级实验焦炉炼制焦炭,分别采用蒸汽熄焦与水熄焦方式对40 kg焦炉炼制的焦炭进行冷却,检测熄焦后焦炭的工业分析、机械强度及热性质等性能指标,对比分析2种熄焦方式对焦炭质量的影响,并研究2种熄焦方式下焦炭与生产干熄焦的焦炭质量关系。结果表明,相对水熄焦,蒸汽熄焦的焦炭水分较稳定(小于1%)、成焦率有所提升,改善了焦炭质量,其中1/3焦煤冷强度的改善最为明显,气煤与1/3焦煤的热性质改善最为明显,肥煤的成焦率提升最大;蒸汽熄焦与生产干熄焦的焦炭质量指标更接近,机械强度M 40一致、M 10数据高出2.5个百分点,热性质CRI数据高出8.1个百分点、CSR低出10.4个百分点。焦化企业可参照试验结果,进一步优化40 kg实验焦炉熄焦工艺及调整生产与试验焦炉的相关性。     

不同水含量下氧化石墨烯改性水泥材料界面性能的模拟研究

水含量会影响硅酸盐材料的机械性能.本文采用分子动力学方法(Molecular Dynamics,MD),研究了0％ 、50％ 、100％ 三种水含量下氧化石墨烯/托贝莫来石(GO/C-S-H)界面的机械性能.研究发现界面连接主要由Caw-Os(C-S-H硅链中的氧原子)、Caw-Ocoo(氧化石墨烯表面去质子化的羧基)、Caw-Ooh(氧化石墨烯表面的羧基)、Caw-Ooo(氧化石墨烯表面的环氧基)以及界面氢键组成,其中Caw-Os和Caw-Ocoo在受到水分子影响时比较稳定,而Caw-Ooh、Caw-Ooo在受到水分子影响时化学稳定性会下降.不同水含量模型的单轴拉伸结果表明,界面机械性能会随着水含量的增加而降低,界面应力最大值从1.1 MPa下降到0.7 MPa.     

Design,Synthesis and Evaluation of 2,4-Diaminoquinazoline Derivatives as Potential Tubulin Polymerization Inhibitors

Microtubules are highly dynamic polymers composed of α- and β-tubulin proteins that have been shown to be potential therapeutic targets for the development of anticancer drugs. Currently, a wide variety of chemically diverse agents that bind to β-tubulin have been reported. Nocodazole (NZ) and colchicine (COL) are well-known tubulin-depolymerizing agents that have close binding sites in the β-tubulin. In this study, we designed and synthesized a set of nine 2,4-diaminoquinazoline derivatives that could occupy both NZ and COL binding sites. The synthesized compounds were evaluated for their antiproliferative activities against five cancer cell lines (PC-3, HCT-15, MCF-7, MDA-MB-231, and SK-LU-1), a noncancerous one (COS-7), and peripheral blood mononuclear cells (PBMC). The effect of compounds 4 e and 4 i on tubulin organization and polymerization was analyzed on the SK-LU-1 cell line by indirect immunofluorescence, western blotting, and tubulin polymerization assays. Our results demonstrated that both compounds exert their antiproliferative activity by inhibiting tubulin polymerization. Finally, a possible binding pose of 4 i in the NZ/COL binding site was determined by using molecular docking and molecular dynamics (MD) approaches. To our knowledge, this is the first report of non-N-substituted 2,4-diaminoquinazoline derivatives with the ability to inhibit tubulin polymerization.     

管壳式换热器内孔焊接残余应力特性研究

常规焊接会使管壳式换热器的换热管与管板之间形成一定的缝隙。换热器长期处于腐蚀性介质环境中,因此易产生缝隙腐蚀和应力腐蚀开裂,通过内孔焊接的方式可有效降低这类腐蚀风险。以Q245材料为研究对象,利用ABAQUS软件对焊接过程中温度场、应力场进行了模拟,研究了管壳式换热器内孔焊接的残余应力分布、设备变形情况,以及不同内孔焊结构残余应力和变形程度的差异,总结了焊接工艺参数对深孔焊接残余应力的影响规律。研究结果表明:全对接型接头的应力集中范围更小,设备应力分布更均匀、变形量较小,焊缝质量较高、承载能力较强。     

液压约束活塞发动机的流量脉动仿真分析

为研究间隙误差对液压约束活塞发动机流量脉动的影响,在ADAMS中建立其含有间隙误差的主运动系统动力学模型,将ADAMS中得到的模型数据导入AMESim中,建立液压系统模型。通过对比不同间隙误差模型的参数输出,分析间隙误差对系统流量脉动的影响。研究结果表明,在一定范围内,间隙误差对流量脉动有明显的影响,并随着间隙误差的增大而增加;而且,连杆大头和曲轴曲柄之间转动副径向间隙误差对系统流量脉动的影响最大。     

基于机器视觉的白色衣物脏污程度分析方法研究

随着生活水平的提高,衣服的干净整洁已经是基本要求,智能衣物洗护已经渗透到我们生活中,了解污渍的脏污程度对于洗衣机和洗涤剂行业显得尤为重要.计算机机器视觉分析快速,结果客观、准确,可重复性强,目前应用广泛.影响污渍脏污程度评价的因素有面积、颜色、纹理等,为了简化研究,本文提出一种基于计算机机器视觉的图像分析技术对白色衣物脏污程度分析的方法,通过图像采集系统得到污渍的图像,对其进行灰度化处理,得到图像的灰度值,进而对污渍脏污程度进行分析判断.结果表明,图像的灰度值可以用来表征白色衣物污渍的脏污程度,且判断结果与主观目视结果具有较高的一致性.     

Towards performance improved anion exchange membrane: Cross-linking with multi-cations oligomer modified graphene oxide

Cross-linking structure has been proven to be an effective approach to address the balance issue between ionic conductivity, dimensional stability and other properties of anion exchange membranes (AEMs). Here, a novel multi-cationic oligomer was synthesized from 1,4-diazabicyclo [2,2,2]octane and 1,6-dibromohexane, and subsequently used to prepare multi-cationic oligomer brushes-decorated graphene oxide (QBGO). The obtained QBGO was employed as the cross-linker to form cross-linked poly (arylene ether sulfone) (QPAES) AEMs by end-cap tertiary amine coupling reaction. Benefiting from the introduction of the multi-cations and flexible long-chain cross-linker structure, the cross-linked QPAES/QBGO membranes formed hydrophilic/hydrophobic phase-separation microstructures and well-defined ionic channels which are responsible for water uptake and ion transfer. As a result, the cross-linked QPAES/QBGO-2.0 membrane exhibited 1.90-fold higher ionic conductivity and better chemical stability than the control QPAES membrane. The QPAES/QBGO-2.0 membrane displayed a higher power density of 75.7 mW cm^?2 than that of the control QPAES membrane (53.1 mW cm^?2) in a H₂/O₂ fuel cell test. In a word, we propose that this novel design strategy holds broad prospects for the design of new polymer electrolyte membrane materials.